ACY-1215

Product Name: ACY-1215
CAS No.: 1316214-52-4
Chemical Name: ACY-1215
Synonyms: ACY 63;CS-583;ACY-1215;Propane-1;Ricolinostat;Rocilinostat;ACY-1215/ACY1215;Rocilinostat, >=99%;3-tricarboxylic acid;β-Carboxyglutaric acid
CBNumber: CB82627292
Molecular Formula: C24H27N5O3
Formula Weight: 433.5
MOL File: 1316214-52-4.mol

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ACY-1215 Property

Melting point:: 189 - 191°C
Density: 1.239±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 9.47±0.20(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21531
Product name: ACY-1215
Purity: ≥98%
Packaging: 25mg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 21531
Product name: ACY-1215
Purity: ≥98%
Packaging: 50mg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 21531
Product name: ACY-1215
Purity: ≥98%
Packaging: 100mg
Price: $228
Updated: 2024/03/01

Cayman Chemical

Product number: 21531
Product name: ACY-1215
Purity: ≥98%
Packaging: 250mg
Price: $494
Updated: 2024/03/01

TRC

Product number: D486990
Product name: 2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide
Packaging: 250mg
Price: $275
Updated: 2021/12/16

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ACY-1215 Chemical Properties,Usage,Production

Description

ACY-1215 is an inhibitor of histone deacetylase 6 (HDAC6; IC₅₀ = 5 nM). It is at least 10-fold less active against other HDACs in enzymatic assays. ACY-1215 shows synergistic activity with the proteasome inhibitor bortezomib against multiple myeloma (MM) cells, inducing protracted endoplasmic reticulum stress and apoptosis. ACY-1215 combined with proteasome inhibitors suppresses tumor growth and increases survival in mice with MM and mantle cell lymphoma xenografts. A multicenter phase I trial examining ACY-1215 combined with the E3 ligase inhibitor lenalidomide and dexamethasone in multiple myeloma found inhibition of HDAC6 in vivo. ACY-1215 also diminishes liver cyst development and fibrosis in a rat model of polycystic liver disease.

Uses

This compound acts as a selective HDAC-6 (histone deacetylase) inihibitor. HDAC is linked to the transcription of DNA in cancers, including multiple myeloma (MM).

Definition

ChEBI: N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)-5-pyrimidinecarboxamide is a pyrimidinecarboxylic acid.

target

HDAC6

ACY-1215 Preparation Products And Raw materials

Raw materials

Preparation Products

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ACY-1215 Suppliers

Canada 1 China 144 India 1 United Kingdom 1 United States 18 Global 165

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

ApexBio Technology LLC

Tel: +1-832-696-8203
Fax: +1-832-641-3177
Email: info@apexbt.com
Country: United States
ProdList: 477
Advantage: 60

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63711
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

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View Lastest Price from ACY-1215 manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: ACY-1215 1316214-52-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-29

Henan Aochuang Chemical Co.,Ltd.

Product: ACY-1215 1316214-52-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

1316214-52-4, ACY-1215Related Search:

Panobinostat Mocetinostat (MGCD0103) Tubastatin-A Tubastatin A hydrochloride Entinostat Crizotinib

Rocilinostat (ACY-1215)

2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide

ACY 63

2-(DiphenylaMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide

RICOLINOSTAT;ACY1215;ACY 1215

Rocilinostat, >=99%

5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-

2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide ACY 1215

Ricolinostat

N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide

Parathyroid hormone - Shire

ACY-1215

Rocilinostat

ACY-1215 (Rocilinostat)

ACY-1215/ACY1215

Ricolinostat (ACY-1215)

CS-583

ROCILINOSTAT; ACY1215; ACY 1215;RICOLINOSTAT

1316214-52-4 ACY1215,ROCILINOSTAT

7-{[2-(Diphenylamino)pyrimidin-5-yl]formamido}-N-hydroxyheptanamide

3-tricarboxylic acid

Propane-1

β-Carboxyglutaric acid

ACY-1215 ACY-63 Ricolinostat ACY1215

2- (Diphenylamino) - N - [7- (hydroxyamino) -7-oxoheptyl] -5-pyrimidine carboxylamide

1316214-52-4

Inhibitors

Inhibitor